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Excellent PDF documents... Medline Searches can be done here... The links are proceeded by a description. The following article is one of the grand-daddy of all modern T research IMHO. Psychosom Me d 1987 Jul-Aug;49(4):397-409 Related Articles, Links Sherwin BB, Gelfand MM. Five aspects of sexual behavior were monitored daily in three groups of women who had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy approximately 4 years ago for benign disease. One group had been receiving an estrogen-androgen preparation intramuscularly once a month since their surgery (E-A). The second group had been receiving estrogen alone (E) and the third group of women had remained untreated. Plasma estradiol and testosterone were measured at an established baseline and again on days 2, 4, 8, 15, 21, and 28 postinjection. Women who received both sex steroids reported higher rates of sexual desire (p less than 0.01), sexual arousal (p less than 0.01), and numbers of fantasies (p less than 0.01) than those who were either given E or who were untreated. Moreover, changes in these behaviors covaried with plasma testosterone but not with plasma estradiol levels during the treatment month as the drug was being metabolized. Rates of coitus and orgasm were also higher in the E-A group during the first two postinjection weeks (p less than 0.01) coincident with their higher testosterone levels. These findings imply that androgen may be critical for the maintenance of optimal levels of sexual functioning in postmenopausal women.
(These are many of the documents that the Princeton consensus statment were based on. All that I've read are very good. FERTILITY AND STERILITY Preface: http://www.fsdinfo.org/pdf/fertil_s4_2002_01.pdf Androgen production in women Aromatization of androgens in women: current concepts and findings Role of androgens in female genital sexual arousal: receptor expression, structure, and function Dehydroepiandrosterone: a springboard hormone for female sexuality Androgens and mammary growth and neoplasia Androgen effects on bone and muscle Hormones, mood, sexuality, and the menopausal transition Randomized clinical trials of combined estrogen-androgen preparations: effects on sexual functioning Sexual effects of androgens in women: some theoretical considerations Androgen deficiency in the oophorectomized woman Androgen deficiency: menopause and estrogen-related factors When to suspect androgen deficiency other than at menopause The hypoandrogenic woman: pathophysiologic overview Estrogen replacement therapy: effects on the endogenous androgen milieu Screening for androgen deficiency in women: methodological and interpretive issues Assessment of female sexual dysfunction: review of validated methods Androgen insufficiency in women: summary of critical issues (20-26) Misc. Materials, most are only applicable to providers. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function postmenopausal women with hypoactive sexual desire. (FERTILITY AND STERILITY VOL. 79, NO. 6, JUNE 2003) Correlation of androgen receptors, aromatase, and 5-a reductase in the human vagina with menopausal status The role of androgen therapy. (Best Practice & Research Clinical Endocrinology & Metabolism Vol. 17, No. 1, pp. 165–175, 2003) TRANSDERMAL TESTOSTERONE TREATMENT IN WOMEN WITH IMPAIRED SEXUAL FUNCTION AFTER OOPHORECTOMY Psychosexual_effects_of_menopause_Role_of_androgens.pdf Testosterone_influences_libido_and_well_being_in_women.pdf Sex_drugs_and_clinical_research.pdf Randomized, Placebo-Controlled, Double Blind, Crossover Design Trial of the Efficacy and Safety of Zestra for Women in Women With and Without Female Sexual Arousal Disorder Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization Determination_of_Testosterone_Production_Rates.pdf Androgen_Replacement_in_Women_A_Commentary.pdf Comparison_of_oral_estrogens_and_estrogens_plus_androgen_on_bone_mineral_density.pdf Low_Dose_Dehydroepiandrosterone_Affects_Behavior.pdf Interpersonal_testosterone_transfer.pdf Pregnancy_the_postpartum_and_steroid_hormones_effects_on_cognition_and_mood.pdf Testosterone_enhances_estradiols_effects_on_postmenopausal_bone_density_and_sexuality.pdf Psychosexual_effects_of_menopause_Role_of_androgens.pdf Twenty-Four-Hour_Mean_Plasma_Testosterone.pdf
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Last Modified 07-06-2003